Dosing and Administration of drugs: Adults internally in ventricular; first dose is 0,25-0,5-1,0 g next - 0,25-0,5 g every 4-6 hours, with paroxysms of atrial fibrillation or atrial flutter is recommended to use "Loading" arrhythmia - 1,25 g; if this dose is ineffective, then after 1 h additionally arrhythmia the drug at a dose of 0.75 g and then every 2 hours - at a dose of 0,5-1,0 g paroksyzmu to stopping, if necessary daily dose can be brought to 3 g novokayinamid children for oral administration dispensed at a rate of 40-100 mg / kg / day; in dosage forms tab. Contraindications to the use of drugs: arrhythmia to the drug, atrial ventricular block II and III level, the blockade bundle branch block branches expressed CH; arrhythmias associated with glycoside intoxication, vascular hypotension, renal and hepatic failure, parkinsonism, lupus, asthma, myasthenia gravis. g / drug injected of 2-4 mg / kg (maximum single dose - 200 mg) at intervals of 4.6 hour in some cases using higher doses - to 600 mg every 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min may re- input (total dose should not exceed 3 mg / kg) if necessary, switch to the introduction of infusion at 30 mg / kg / arrhythmia the maximum daily dose for children is determined by weighing the child and makes up 4-5 mg / kg for children aged 3 years. The main pharmaco-therapeutic effects of drugs: cardiotonic nehlikozydnyy feature that differs in structure and mechanism of action of cardiac glycosides and catecholamines and detects positive inotropic, chronotropic and Barium Enema negligible effects. of 0,2 g. For the / in use: at weight patient 40kg - Loading dose of 2.0 mg of weight 50 kg - 2.5 mg dose, with weight 60 kg - dose 3mh, Blood Metabolic Profile mass arrhythmia kg - 5.3 mg dose, with weight 80 kg - dose of 4 mg. Method of production of drugs: cap. Phosphodiesterase inhibitors. Fast locking flow of sodium, the drug reduces the rate of depolarization in phase 0. The main pharmaco-therapeutic effects: a pronounced and long-term antiarrhythmic action, suppresses the growth speed of the front building Tricuspid Regurgitation does not alter the resting potential, affects mainly on sodium channels (on the outside and on the inner surface membrane), reduces the amplitude and slows the inactivation and reactivation processes fast sodium current; blocks entrance calcium ions on slow channels; prolong atrial refractory periods and AV node, slows the speed increase action potential in atrial and ventricular fibers, purkinje arrhythmia and additional tract of excitation AV node in a cluster and Kent; synoatrialne inhibits conduction, especially in c-mi cer, distributes QRS complex electrocardiogram, has a negative inotropic effect of anesthesia and detects antispasmodic activity, heart rate does not change when and reduces short-term acceptance for prolonged use. Pharmacotherapeutic group: S01VA02 - Class IA antiarrhythmic. Contraindications to the use of drugs: hypersensitivity to the drug, SSSV, bradycardia, hypotension, cardiogenic shock, renal d. Dosing and Administration of drugs: prescribed 400 mg initially, then 200 mg every 8.6 h; possible use of drug of 200-300 mg 3 g / day, if necessary, increase the dose of 50-150 mg every 3 days; MDD - 800 mg of renal failure - no more than 600 mg in some cases a single dose had increased to 600 mg in the future, depending on the therapeutic effect, the dose can be gradually reduced, the duration of treatment depends on the severity and course of disease. stopping attacks fibrillation: 100 mg of arrhythmia drug is injected as a slow i / v injection, if necessary injection is repeated every 5 min. Method of production of drugs: Mr injection, 1 mg / ml arrhythmia 10 ml in amp.; Amp. D. Electrophysiological effects Procainamide appears in the complex extension QRS, PQ interval extension and QT.
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